
Dabigatran etexilate
CAS No. 211915-06-9
Dabigatran etexilate( BIBR-1048 )
Catalog No. M13373 CAS No. 211915-06-9
A prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 30 | In Stock |
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5MG | 47 | In Stock |
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10MG | 65 | In Stock |
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50MG | 80 | In Stock |
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100MG | 108 | In Stock |
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200MG | 158 | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameDabigatran etexilate
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NoteResearch use only, not for human use.
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Brief DescriptionA prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM.
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DescriptionA prodrug of BIBR-953, which is a potent nonpeptide thrombin inhibitor with Ki of 4.5 nM; 10-fold less potent for Trypsin and no activity against Factor Xa, Plasmin, tPA and activated protein C; exhibits strong and long-lasting anticoagulant effects ex vivo and strong oral activity in different animal species.Thrombosis Approved(In Vitro):Dabigatran etexilate (BIBR 1048; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively.Dabigatran etexilate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively.Dabigatran etexilate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey.
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In Vitro——
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In VivoDabigatran etexilate (BIBR 1048; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively. Dabigatran etexilate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively.Dabigatran etexilate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey. Animal Model:Male rats (280-350 g) and rhesus monkeys of either sex (3-8 kg)Dosage:10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys Administration:Oral Result:Had dose- and time-dependent anticoagulant effects.
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SynonymsBIBR-1048
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PathwayAutophagy
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TargetThrombin
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RecptorThrombin
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number211915-06-9
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Formula Weight627.7332
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Molecular FormulaC34H41N7O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(OCC)CCN(C1=NC=CC=C1)C(C2=CC=C3N(C)C(CNC4=CC=C(/C(N)=N\C(OCCCCCC)=O)C=C4)=NC3=C2)=O
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Chemical Nameb-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hauel NH, et al. J Med Chem. 2002 Apr 25;45(9):1757-66.
2. Wienen W, et al. Thromb Haemost. 2007 Jul;98(1):155-62.
3. Baetz BE, et al. Pharmacotherapy. 2008 Nov;28(11):1354-73.
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